The golden egg in physics is a unified theory of everything. You make attempts, you fail and it’s back to the drawing board.
Things in science work really well until a discovery is made and we discover it doesn’t work as well anymore. Back to the drawing board.
We cannot interpret religious texts with our current language because the meaning has radically transformed over the years. Every time we unearth the real meaning, we have a whole new understanding of their level of thinking. Then it’s back to the drawing board.
It was impossible to run a mile in four minutes, until it was done once… then several times. Back to the drawing board on our understanding of the potential of human limits.
We don’t have all the answers, just current ones.
Nobody really knows what the next answer will be, but when we get there, it’ll be back to the drawing board.